Promethazine HCl and Codeine Phosphate Oral Resolution ought to be utilized with caution in clients with intense impairment of renal perform, and sufferers must be monitored intently for respiratory despair, sedation, and hypotension.
Anticholinergics – Concomitant utilization of other agents with anticholinergic Qualities should be carried out with caution.
Get health care enable straight away In case you have any really major side effects, which include: sluggish/shallow respiratory, seizures.
Excessively massive dosages of antihistamines, including promethazine hydrochloride, in pediatric patients may possibly induce sudden death (see OVERDOSAGE). Hallucinations and convulsions have transpired with therapeutic doses and overdoses of promethazine hydrochloride in pediatric sufferers. In pediatric patients who are acutely ill connected to dehydration, There is certainly an elevated susceptibility to dystonias with the use of promethazine HCl.
Bodily dependence, the ailment wherein continued administration with the drug is needed to circumvent the looks of a withdrawal syndrome, assumes clinically major proportions only just after quite a few weeks of continued oral opioid use, While some mild degree of physical dependence might create just after a few days of opioid therapy.
In patients receiving MAO inhibitors, an Preliminary smaller take a look at dose is highly recommended to allow observation of any extreme narcotic results or MAOI conversation.
The subsequent major adverse reactions are described, or described in increased detail, in other sections:
The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric individuals lower than six years of age, since the combination may well bring about fatal respiratory depression in this age inhabitants (see WARNINGS – Box Warning and Use In Pediatric Patients).
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Very carefully evaluate the dose employing a Distinctive measuring product/spoon. Usually do not utilize a home spoon simply because you may not get the correct dose.
Treatment of Overdose Procedure of overdosage is pushed by the overall scientific presentation, and contains discontinuation of Promethazine HCl and Codeine Phosphate Oral Option together with institution of suitable therapy. Give Principal attention towards the reestablishment of adequate respiratory Trade by means of provision of a patent and protected airway and also the establishment of assisted or managed ventilation.
Very low blood pressure. A sudden drop in blood pressure level can happen in many people through cure with Promethazine Hydrochloride and Codeine Phosphate Oral Solution which may bring about you to definitely come to feel dizzy, faint, lightheaded, or weak, particularly when you get up (orthostatic hypotension). Your danger of having this problem could be amplified if you take Promethazine Hydrochloride and Codeine Phosphate Oral Resolution with specified other medicines that decrease blood pressure level.
Dosing The dose of this drugs will likely be different for various people. Stick to your medical professional's orders or even the Instructions within the label. The subsequent information involves only the normal doses of this medicine. If your dose differs, do not adjust it Except your health practitioner informs you to take action.